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. 2016 Sep 1;101(11):4478–4488. doi: 10.1210/jc.2016-1333

Figure 1.

Figure 1.

ADM2, CRLR, and RAMPs levels in preeclamptic and normotensive pregnant women. A, An EIA showing a lower level of ADM2 at term in preeclamptic pregnant women (PreE) compared with the gestational age-matched normal (control) (P < .05; n = 7–8). B, Expression of ADM2 mRNA in the villous tissue from PreE compared with the gestational age-matched normal placenta (control). C, ADM2 immunoreactivity in placental villi from normal (control) and PreE pregnancy. As shown, immunoreactivity for ADM2 is lower throughout the villous tissue in PreE compared with the control villi. IgG was used as negative control (-ve IgG) and 4′, 6-diamidino-2-phenylindole (DAPI) was used for blue nuclear staining. Bar graph shows ADM2 immunostaining relative to DAPI. Data are presented as mean ± SEM. *, P < .05 (magnification, ×200, n = 3). D, Expression of CRLR and RAMP mRNA in the placental villous tissue. The bar graphs represent mRNA levels of CRLR and RAMP1, RAMP2, and RAMP3 in villous tissue from normal pregnant women (control, n = 8) and women with PreE (n = 8) normalized to GAPDH mRNA expression. Data are presented as mean ± SEM. *, P < .05.