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. 2016 Oct 27;7:13257. doi: 10.1038/ncomms13257

Figure 2. GEM TCR footprint on CD1b–GMM.

Figure 2

(a) Footprint of the GEM42 TCR on the surface of CD1b (white) and GMM (pale orange spheres) is represented according to the atoms contacted and coloured as per the TCR segment making contact. Framework residue from the α-chain in pale pink, the CDR loops coloured in teal (CDR1α), green (CDR2α) and purple (CDR3α) for the α-chain and red (CDR1β), orange (CDR2β) and yellow (CDR3β) for the β-chain, respectively. Pink and blue spheres represent the centre of mass of the GEM42 TCR α and β-chains, respectively. The insert below the footprint represents the characteristic CDR3α loop sequence of the GEM TCR. GEM42 TCR interactions with the CD1b (panels b–f), with the CD1b in white, GMM in pale orange and the GEM 42 TCR coloured as per panel (a). The panels represent residues from the (b) the CDR1α (teal); (c) CDR2α (green) and framework residue from α-chain (pale pink); (d) CDR3α (purple); (e) CDR1/2β (red and orange) and framework β-chain (pale blue); (f) CDR3β (yellow) interacting with the CD1b molecule (white). Hydrogen bonds are shown as red dashed lines, and the sphere represents the Cα atom of the glycine 29α residue.