Figure 8. mTORC2 regulates epidermal differentiation during embryogenesis.
(a) Toluidine blue dye penetration assay of RicEKO and control embryos at E17.5 and E18.5, and the quantification of the blue stained area (n=5 embryos/genotype). (b) Representative H&E-stained back skin of embryos at E16.5 and E17.5 and quantification of epidermal thickness (n=5 embryos/genotype). (c) qRT-PCR analysis and (d) western blotting analysis of gene expression in RicEKO and control epidermis at E17.5 (n=5 embryos/genotype). Data represents mean±s.d.; non-paired t-test was used to calculate P value. *P<0.05, **P<0.01, ***P<0.001.