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Pretreatment with FA alleviated the levels of serum TNF-α and 1L-1β in APAP-challenged mice. Mice were given oral gavage of vehicle or FA (100 mg/kg) every 8 h one time for three times within 24 h before APAP (350 mg/kg) exposure and serum were collected at 18 h after APAP administration. The serum TNF-α (A) and 1L-1β (B) were detected by ELISA. Data were expressed as mean ± SD, n=6, **P<0.01, as compared with APAP group.
