Table 1.
GO analysis of differentially expressed cytokines in conditioned media
| GO TERM/GO ID | H/R vs. Normal | H/R vs. Normal | TXL vs. H/R | TXL vs. H/R |
|---|---|---|---|---|
| Up-regulated | Down-regulated | Up-regulated | Down-regulated | |
| Positive regulation of cell proliferation GO:0008284 | IL-21 | VEGF R2; IL-7; PDGF-AB; IL-2; bFGF; SCF R; PDGF-BB | IL-24; G-CSF; VEGF R2; VEGF; SCF R; GM-CSF; IL-6 | VEGF-C; PDGF-AB; IGF-II R; bFGF; APRIL; IL-21; AR; IL-6 sR; NT-3; PDGF-BB; IL-7; EG-VEGF; ENA-78; FGF-19; MCSF; FGF-4; IGF-I; IL-11; BAFF; FGF-7; cripto-1; IP-10 |
| Negative regulation of cell proliferation GO:0008285 | GROα; BMP-2; 4-1BB | bFGF; BMP-4 | IL-24; IL-6; TNF RII; TNF RI | IGFBP-3; BMP-2; IL-1 R6; BMP-4; bFGF; IL-6 sR; MPIF-1; GROα; sFRP-3; angiostatin; IGF-I |
| Regulation of cell growth GO:0001558 | ErbB2; IGFBP-1 | bFGF; IL-2; NOV | IGFBP-1; IGFBP-2; VEGF | bFGF; sFRP-3; BMP-9; NRG-1β; IGFBP-3; IGFBP-4; NOV; IL-17B R; CXCL16; WISP-1 |
| Positive regulation of cell differentiation GO:0045597 | IL-21; BMP-2 | bFGF; IL-2; IL-5; IL-7; VEGF R2; BMP-4 | GM-CSF; IL-6; VEGF R2; TNF RI; TNF RII; VEGF | MCSF; bFGF; sFRP-3; BMP-9; NRG-1β; IGF-I; IGFBP-3; IL-4; IL-6 sR; IL-7; IL-12p40; IL-12p70; IL-13 R2; IL-13; SCF; NGFR; NT-3; PF4; angiostatin; IL-21; BDNF; BMP-2; BMP-4; VEGF-C; procalcitonin; TRANCE |
| Negative regulation of cell differentiation GO:0045596 | CRP; BMP-2 | SCF R; BMP-4; follistatin | IL-6; SCF R; TNF RI; TNF RII; follistatin | CRP; FGF-4; DKK-1; sFRP-3; IFNα/β R2; IGF-I; IL-4; IL-6 sR; IL-13 R2; IL-13; NGFR; PF4; BDNF; MIP-1α; BMP-2; BMP-4; procalcitonin |
| Chemotaxis GO:0006935 | GROα; MCP-2 | uPA; bFGF | uPAR; MIP-3α | CXCL16; RANTES; bFGF; MIP-1α; IL-4; MCP-2; MPIF-1; GROα; ENA-78; MIG; C5a; GCP-2; CXCL14; IP-10; HCC-4 |
| Transport GO:0006810 | CRP; adipsin; ferritin; 4-1BB; MCP-2 | bFGF; follistatin; ANG-1; IL-2; IL-5; SCF R; PDGF-AB; PDGF-BB; NOV; BMP-4; LIMPII | GM-CSF; G-CSF; follistatin; albumin; ICAM-1; IL-6; SCF R; lipocalin-2; PECAM-1; PD-1; E-selectin; TNF RI; TNF RII; VEGF | BAFF; AMICA; CRP; adipsin; bFGF; FGF-7; DKK-1; FOLR1; ferritin; ANG-1; NRG-1β; IFNα/β R2; IGF-I; IGF-II R; IL-1 R6; IL-4; IL-6 sR; IL-11; IL-12p40; IL-12p70; IL-13 R2; IL-13; IP-10; AR; NGFR; NT-3; PDGF-AB; PDGF-BB; PF4; NAP-2; angiostatin; CXCL16; NOV; BDNF; MIP-1α; RANTES; MCP-2; BMP-4; C5a; VEGF-C; procalcitonin; TRANCE; LIMPII; FGF-19 |
| Vasculogenesis GO:0001570 | VEGF R2 | VEGF R2; VEGF; endoglin | BMP-9; cripto-1 | |
| Positive regulation of angiogenesis GO:0045766 | ANGPTL4 | VEGF R2; bFGF | VEGF R2; VEGF | BMP-9; IL-1 R6; bFGF; C5a |
| Negative regulation of angiogenesis GO:0016525 | BMP-9; PF4; IP-10 | |||
| Angiogenesis GO:0001525 | ANGPTL4 | VEGF R2 | VEGF R2; VEGF; CEACAM-1 | VEGF-C; EG-VEGF; TGFα; angiostatin |