FIGURE 6.

Parallel analysis of functional protein categories in cRyr2Δ50 hearts. A–C, visualization of the changes of key cardiac proteins arranged into functional clusters of excitation-contraction coupling proteins (A), glycolysis and glucose oxidation proteins (B), or fat oxidation and other key metabolic proteins (C). Data are plotted as the -fold difference between cRyr2Δ50 and control hearts (one sample per group made with four pooled hearts per sample to reduce variation). Red, ≤0.75-fold change; orange, ≤0.85 change; pale green, ≥1.15 enrichment; dark green, ≥1.25 enrichment. Gray schematics show location of presented glucose and fat oxidation proteins in their respective pathways.