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. 2016 Sep 15;291(45):23578–23588. doi: 10.1074/jbc.M116.738930

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Morphological alterations induced by heterozygous expression of catalytically silent Gpx4 are partially reversed by Alox15 knock-out. A, the structure of sperm extracted from the epididymal cauda of male Sec46Ala-Gpx4^+/−+Alox15^+/+ and Sec46Ala-Gpx4^+/−+Alox15^−/− mice were compared by light microscopy as described in the legend to Fig. 2. Sperm were classified as Grade 1 (normal structure, a, grade 2 (slightly disturbed structure, b), and grade 3 (severely disturbed structure, c) sperm. The relative shares of the different sperm classes are indicated by the box plots. For each genotype, five mice were measured. B, electron micrograph of Sec46Ala-Gpx4^+/−+Alox15^+/+ sperm with severe structural alterations (I). Among Sec46Ala-Gpx4^+/−+Alox15^−/− sperm we observed a high degree of structural diversity. Here we found normal looking sperm (III) but also cells with a severely disrupted structure (II). Because of the high degree of interindividual variations, there were no significant differences between the two groups of animals (A, a–c).