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. 2016 Sep 20;149(4):432–446. doi: 10.1111/imm.12662

Figure 6.

Figure 6

Atorvastatin attenuated dextran sodium sulphate (DSS) ‐induced murine chronic colitis. (a) The experimental design. Mice were killed at day 55. Chronic colitis was evaluated by: weight loss (b), disease activity index (DAI) (c), colon length (d) and colon histology (100 ×) and histology score (e). (f) Proportions of myeloid‐derived suppressor cells (MDSCs) (CD11b+ Gr‐1+) in different tissues of mice were evaluated by flow cytometry. Representative graph (left) and statistical graph (right) are shown (n = 5). (g) The representative flow cytometry plots of MDSCs subsets (with CD11b+ cells pre‐gated) in spleen and colon lamina propria mononuclear cells (LPMCs) for DSS and DSS+Ator treatment. For (b) and (c), DSS+Ator group was compared with DSS group. *P < 0·05, **P < 0·01.