Table 2.
List of genes presenting at least fourfold up‐regulation in their expression in macrophages from wild‐type (WT) and NOD1 knockout (NOD1 –/–) mice after a 6‐hr stimulation with heat‐killed Aggregatibacter actinomycetemcomitans (Aa) associated or not with heat‐killed Lactobacillus fermentum (Lf) in comparison to WT untreated control
| Gene name | Aa simulation | Aa+Lf stimulation | ||
|---|---|---|---|---|
| WT | NOD1−/− | WT | NOD1−/− | |
| Ccl2 | 4·40 | 4·00 | 4·03 | |
| Cd14 | 4·45 | |||
| Cd86 | 5·01 | |||
| Clec4e | 5·08 | 10·68 | 9·52 | |
| Csf2 | 6·71 | 26·89 | 17·08 | |
| Csf3 | 16·08 | 14·54 | 16·86 | 22·76 |
| Cxcl10 | 15·60 | 14·62 | 5·92 | 22·85 |
| Ifnb1 | 12·92 | 9·22 | 17·67 | 12·96 |
| Ifng | 6·18 | 11·92 | ||
| Il10 | 13·36 | 11·04 | 13·42 | 19·36 |
| Il12a | 15·28 | 37·58 | 6·67 | 27·24 |
| Il1a | 90·94 | 281·95 | 12·79 | 217·05 |
| Il1b | 45·80 | 166·39 | 12·34 | 159·89 |
| Il2 | 19·11 | |||
| Il6 | 16·56 | 24·77 | 40·05 | |
| Irf1 | 5·29 | 5·45 | ||
| Lta | 4·29 | 4·52 | ||
| Muc13 | 11·19 | |||
| Nfkb1 | 6·59 | 5·40 | ||
| Nfkb2 | 5·39 | 9·16 | 7·79 | |
| Nfkbia | 7·90 | 10·83 | 4·31 | 12·57 |
| Nfkbib | 4·27 | 7·45 | 7·12 | |
| Ptgs2 | 19·23 | 30·43 | 6·28 | 40·60 |
| Rel | 4·83 | 6·44 | ||
| Ripk2 | 4·97 | |||
| Tlr1 | 4·28 | 6·45 | ||
| Tlr2 | 8·12 | 18·21 | 14·10 | |
| Tlr9 | 4·36 | |||
| Tnf | 29·23 | 61·02 | 7·55 | 57·45 |
| Tnfaip3 | 8·32 | 12·89 | 12·67 | |
Data obtained from the analysis of quantitative PCR arrays performed using cDNA prepared from pools of RNA isolated from bone‐marrow‐derived macrophages from six different mice in each experimental condition.