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. 2016 Oct 3;149(4):423–431. doi: 10.1111/imm.12659

Figure 6.

Figure 6

Effect of ATP‐citrate lyase (ACLY) inhibition in lymphoblasts from children with Down syndrome (DS). (a) Reactive oxygen species (ROS), (b) nitric oxide (NO) and (e) lipid peroxidation levels from lympoblastoid cells taken from six children with DS and either untreated (black bars) or treated with 500 μm hydroxycitric acid (HCA) (grey bars) or 5 μm SB‐204990 (white bars) were measured. (c) ROS and NO (d) levels from lympoblastoid cells taken from six children with DS and untreated (black bars) or treated with 500 μm HCA alone (grey bars) or in the presence of NADPH (white bars) or malate (dark grey bars) were measured. In (a), (b), (c), (d) and (e), means ± SD of four replicate independent experiments are shown; where indicated differences between samples and relative controls (*P < 0·05, **P < 0·01) were significant.