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. 2016 Oct 31;7:12849. doi: 10.1038/ncomms12849

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Copyright © 2016, The Author(s)

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(a) Representative image and quantification of aortic root lesion formation and CD68+ macrophage accumulation (green, Alexa 488) in high-fat and high-cholesterol diet-fed LDLR^−/− mice whose bone marrow was reconstituted by PARP14^−/− mice (BMT^PARP14^{−/−→LDLR−/−} mice, n=5), compared with LDLR^−/− mice with PARP14^+/+ bone marrow (BMT^PARP14^{+/+→LDLR−/−} mice, n=6–7). Scale bars, 100 μm. (b) mRNA expression of the aorta from a. n=6–8. (c) Immunofluorescence staining of PARP14 and PARP9 proteins (green, Alexa 488) in human carotid plaques. CD68 (red, Alexa 594). Nuclei (blue, 4,6-diamidino-2-phenylindole, DAPI). Scale bars, 100 μm; insets, 10 μm (n=5). Prevalence of PARP14+ or PARP9+ macrophages in macrophage-poor versus macrophage-rich plaques. *P<0.05 and **P<0.01, respectively, by Student's t-test. Error bars indicate s.d.