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. 2016 Oct 31;7:12849. doi: 10.1038/ncomms12849

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Copyright © 2016, The Author(s)

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(a) Heterogeneity in IFNγ-stimulated compared with unstimulated cells in combined all donor cells (n=520). (b) Similarity map of cells from all donors/conditions reveals three subpopulations; IFNγ-stimulated cells (Cluster 1), unstimulated cells (Cluster 2) and mixed populations (Cluster 3). Cluster 1 inset—there are two further subpopulations within IFNγ-stimulated cells, such as Groups 1 and 2. (c) The relative expression data for genes related to macrophage function are compared between Groups 1 and 2 (n=112 and n=63, respectively). (d) Similarity maps of 91 genes examined. (e) Gene similarity map of PARP9/14, STAT, JAK and IRF genes based on analysis with all cells from all donors and conditions. *P<0.05 and **P<0.01, respectively, by Student's t-test. Error bars indicate s.d.