Table 10. Cytotoxicity of the EtOAc extracts of fungal metabolites under 0.5% NaFa,b.
| Strain No. | K562 (%) | Fungal medium 2# |
SWS medium |
|||
|---|---|---|---|---|---|---|
| MCF-7 (%) | A549 (%) | K562 (%) | MCF-7 (%) | A549 (%) | ||
| OUCMDZ4118 | 79.32 ± 0.18 | 86.23 ± 0.25 | 84.15 ± 0.01 | 79.71 ± 0.61 | 60.19 ± 0.01 | 61.41 ± 0.01 |
| OUCMDZ4122 | 62.90 ± 0.33 | 79.23 ± 0.37 | 79.16 ± 0.07 | 85.06 ± 0.82 | 63.99 ± 0.14 | 61.53 ± 0.03 |
| OUCMDZ4130 | 57.19 ± 0.65 | 84.49 ± 0.004 | 85.09 ± 0.72 | 85.65 ± 1.12 | 64.06 ± 0.02 | 57.35 ± 0.17 |
| OUCMDZ4131 | 17.36 ± 0.07 | 76.61 ± 0.01 | 63.97 ± 0.002 | 3.89 ± 0.03 | 49.85 ± 0.02 | 1.91 ± 0.49 |
| OUCMDZ4134 | 63.20 ± 0.52 | 87.40 ± 0.07 | 75.72 ± 0.05 | 89.37 ± 0.02 | 72.25 ± 0.21 | 77.72 ± 0.02 |
| OUCMDZ4136 | 40.90 ± 0.34 | 75.35 ± 0.06 | 65.77 ± 0.01 | 87.70 ± 0.19 | 80.00 ± 0.02 | 66.61 ± 0.07 |
| OUCMDZ4137 | 80.86 ± 0.01 | 61.68 ± 0.22 | 73.00 ± 0.25 | 26.73 ± 1.07 | 66.88 ± 0.24 | 50.59 ± 0.01 |
| OUCMDZ4145 | 50.36 ± 0.66 | 88.07 ± 0.45 | 87.74 ± 0.01 | 12.59 ± 4.10 | 55.43 ± 0.04 | 64.87 ± 0.21 |
aEach datum represents the average inhibition and the standard deviation of three independent experiment.
bThe inhibitions of adriamycin (positive control) at 1 μM for K562, MCF-7 and A549 were 87%, 60% and 83%, respectively.