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. 2016 Nov 4;6:36496. doi: 10.1038/srep36496

Table 9. Cytotoxicity of the EtOAc extracts of actinobacterial metabolites under NaFa , b.

Strain No.c K562 (%) 2% NaF
3% NaF
8% NaF
10% NaF
MCF-7(%) A549 (%) K562 (%) MCF-7(%) A549 (%) K562 (%) MCF-7(%) A549 (%) K562 (%) MCF-7(%) A549 (%)
OUCMDZ4173 32.88 ± 0.04 63.96 ± 0.17 −4.55 ± 0.37 48.50 ± 0.06 69.97 ± 0.28 −6.81 ± 0.02 −4.53 ± 0.19 45.53 ± 0.11 7.89 ± 0.09 2.47 ± 0.07 67.20 ± 0.09 18.25 ± 0.01
OUCMDZ4174 6.99 ± 0.12 58.46 ± 0.07 29.64 ± 0.05 58.54 ± 0.23 54.43 ± 0.03 −6.63 ± 0.24 11.36 ± 0.45 27.62 ± 0.18 43.90 ± 0.08 −3.55 ± 0.83 63.23 ± 0.29 17.39 ± 0.09
OUCMDZ4176 9.73 ± 0.07 76.67 ± 0.38 29.73 ± 0.36 −2.51 ± 0.59 71.91 ± 0.54 13.80 ± 0.04 36.81 ± 0.36 66.83 ± 0.65 36.64 ± 0.13 4.08 ± 0.58 72.68 ± 0.04 28.20 ± 0.06
OUCMDZ4177 8.43 ± 0.03 56.66 ± 0.01 13.86 ± 0.08 43.68 ± 0.56 46.93 ± 0.37 31.90 ± 0.12 1.82 ± 0.56 51.40 ± 0.05 10.15 ± 0.06 5.02 ± 0.54 51.79 ± 0.11 35.47 ± 0.15
OUCMDZ4179 21.67 ± 0.16 32.40 ± 0.92 42.81 ± 0.81 26.88 ± 0.04 74.63 ± 0.08 −282.72 ± 0.73 29.29 ± 0.62 63.17 ± 0.06 22.74 ± 0.06 1.62 ± 0.53 75.98 ± 0.012 13.51 ± 0.01

aEach datum represents the average inhibition and the standard deviation of three independent experiment.

bThe inhibitions of adriamycin (positive control) at 1 μM for K562, MCF-7 and A549 were 73%, 71% and 74%, respectively.

cCultured in the actinobacterial medium 2#.