Table 9. Cytotoxicity of the EtOAc extracts of actinobacterial metabolites under NaFa , b.
Strain No.c | K562 (%) | 2% NaF |
3% NaF |
8% NaF |
10% NaF |
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
MCF-7(%) | A549 (%) | K562 (%) | MCF-7(%) | A549 (%) | K562 (%) | MCF-7(%) | A549 (%) | K562 (%) | MCF-7(%) | A549 (%) | ||
OUCMDZ4173 | 32.88 ± 0.04 | 63.96 ± 0.17 | −4.55 ± 0.37 | 48.50 ± 0.06 | 69.97 ± 0.28 | −6.81 ± 0.02 | −4.53 ± 0.19 | 45.53 ± 0.11 | 7.89 ± 0.09 | 2.47 ± 0.07 | 67.20 ± 0.09 | 18.25 ± 0.01 |
OUCMDZ4174 | 6.99 ± 0.12 | 58.46 ± 0.07 | 29.64 ± 0.05 | 58.54 ± 0.23 | 54.43 ± 0.03 | −6.63 ± 0.24 | 11.36 ± 0.45 | 27.62 ± 0.18 | 43.90 ± 0.08 | −3.55 ± 0.83 | 63.23 ± 0.29 | 17.39 ± 0.09 |
OUCMDZ4176 | 9.73 ± 0.07 | 76.67 ± 0.38 | 29.73 ± 0.36 | −2.51 ± 0.59 | 71.91 ± 0.54 | 13.80 ± 0.04 | 36.81 ± 0.36 | 66.83 ± 0.65 | 36.64 ± 0.13 | 4.08 ± 0.58 | 72.68 ± 0.04 | 28.20 ± 0.06 |
OUCMDZ4177 | 8.43 ± 0.03 | 56.66 ± 0.01 | 13.86 ± 0.08 | 43.68 ± 0.56 | 46.93 ± 0.37 | 31.90 ± 0.12 | 1.82 ± 0.56 | 51.40 ± 0.05 | 10.15 ± 0.06 | 5.02 ± 0.54 | 51.79 ± 0.11 | 35.47 ± 0.15 |
OUCMDZ4179 | 21.67 ± 0.16 | 32.40 ± 0.92 | 42.81 ± 0.81 | 26.88 ± 0.04 | 74.63 ± 0.08 | −282.72 ± 0.73 | 29.29 ± 0.62 | 63.17 ± 0.06 | 22.74 ± 0.06 | 1.62 ± 0.53 | 75.98 ± 0.012 | 13.51 ± 0.01 |
aEach datum represents the average inhibition and the standard deviation of three independent experiment.
bThe inhibitions of adriamycin (positive control) at 1 μM for K562, MCF-7 and A549 were 73%, 71% and 74%, respectively.
cCultured in the actinobacterial medium 2#.