Table 2. Retargeted FVs integrate within satellite repeat elements.
| Vector | Total sites | Percent of RIS |
|||||
|---|---|---|---|---|---|---|---|
| Centromerea | In repeat elements |
||||||
| LINE | SINE | Satellite | DNA | LTR | |||
| ControlIMR90 | 2306 | 3.9 | 20.9 | 20.7 | 2.4 | 2.6 | 7.3 |
| IN-CBX1IMR90 | 3994 | 4.7** | 16.5*** | 18.4*** | 3.1** | 2.8 | 8.6** |
| Gag-RTYIMR90 | 3382 | 37.0*** | 16.0*** | 13.1*** | 36.2*** | 1.5*** | 4.8*** |
| IN-CBX1 & Gag-RTYIMR90 | 2224 | 37.1*** | 18.8*,### | 15.7***,### | 36.2*** | 1.1*** | 4.1*** |
| ControlCD34 | 5351 | 1.3 | 16.8 | 22.7 | 1.0 | 2.3 | 7.5 |
| IN-CBX1 & Gag-RTYCD34 | 3175 | 26.8*** | 16.5 | 18.3*** | 31.1*** | 1.4*** | 5.7*** |
| Random | 10000 | 3.5 | 21.0 | 12.8 | 0.4 | 3.5 | 9.6 |
**Statistically significant at p < 0.01 compared to control vector.
***Statistically significant at p < 0.001 compared to control vector.
###Statistically significant at p < 0.001 compared to Gag-RTY vector.
aLess than 1 Mbp from centromere. RIS, retroviral vector integration sites.