Table 1. Initial conditions and parameters for numerical simulations of apoptosis induction in mitotic arrest.

Initial conditions/parameter values	Value	Units	Description
[B1], [B2], [B4], [B8], [B16], [B32], [B64], [B128], [B256]	0.0	nM	Bak oligomeric species
[M]	3000.0	nM	Free Mcl-1
[MB]	1000.0	nM	Mcl-1/Bak complex
[Cm]	1000.0	nM	Mitochondrial CytC
[Cc]	0.0	nM	Cytoplasmic CytC
σM	5 × 10−6	nM/s	Mcl-1 synthesis rate in mitosis
δM	1.3 × 10−4	1/s	Mcl-1 degradation rate in mitosis
αM	0.05	1/nM/s	Bak/Mcl-1 association rate
βM	0.5	1/s	Bak/Mcl-1 dissociation rate
γm	5000.0 (Model I) 0.5 (Model II)	1/nM/s	CytC cytoplasmic translocation rate
γC	0.5	1/s	CytC mitochondrial translocation rate
α1→2	0.05	1/nM/s	Bak dimerization rate
β1→2	500.0	1/s	Bak dimer dissociation rate
α2→4	0.05	1/nM/s	Bak tetramer association rate
β2→4	0.05	1/s	Bak tetramer disassociation rate
αi→j	1	1/nM/s	Association rates of all other oligomers
βi→j	1	1/s	Dissociation rates of all other oligomers