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. 2016 Oct 11;5(10):e373. doi: 10.1038/mtna.2016.64

Figure 1.

Figure 1

Upregulation of OA-associated genes in response to rhIL1B. (a) RT-qPCR analysis of IL1B, IL8, and MMP13 mRNA levels after stimulating ACs with increasing doses of rhIL1B. (b) RT-qPCR analysis of IL1B, IL8, and MMP13 mRNA levels after stimulating bone-marrow-derived mesenchymal stem cells (BM-MSCs) with increasing doses of rhIL1B. (c) Expression of IL1B, IL6, IL8, and MMP13 during 48 hours of stimulation with rhIL1B 0.1 ng/ml. (d) Expression of IL1B, IL6, IL8, and MMP13 during 7 days of stimulation with rhIL1B 0.1 ng/ml. Cells used in a, b, c, and d are from four different donors. Numbers in parentheses indicate relative fold change values relative to time zero or the first detectable value. N.D, not detected; OA, osteoarthritis; IL1B, interleukin 1β; RT-qPCR, real time-quantitative polymerase chain reaction; rhIL1B, recombinant human IL1B; MMP13, matrix metalloprotein 13.