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. 2016 Oct 11;5(10):e374. doi: 10.1038/mtna.2016.80

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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miR-155 directly targets Pea15a. (a) Pea15a was inversely regulated by miR-155 at mRNA level in heart tissues (n = 4). (b) Pea15a was inversely regulated by miR-155 at protein level in heart tissues (n = 4). (c) Sequences of miR-155 binding site on Pea15a 3′UTR as well as mutated Pea15a 3′UTR are shown here. (d) HEK293 cells were transfected with the wild-type or the mutated Pea15a 3′UTR together with miR-155 agomiR or miRNA negative control, and luciferase activities were measured as described in “Materials and methods” (n = 3). *P < 0.05; **P < 0.01; ***P < 0.001.