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. 2016 Oct 11;5(10):e375. doi: 10.1038/mtna.2016.82

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Notch-1 expression is increased in DTX-treated LAD and associated with poor prognosis LAD patients. (a) Notch-1 expression in surgical resection specimens by immunohistochemistry staining. (b) The Kaplan–Meier univariate analysis for the association of Higher Notch-1 expression, advanced TNM stage and poorer survival time, including disease-free survival (DFS) and overall survival (OS). (c) mRNA and (d) protein levels of Notch-1 in two parental LAD cell lines SPC-A1 and H1299 and their DTX-resistant cell lines. (e) mRNA and protein levels of Notch-1 in two parental LAD cell lines treated with DTX in different concentration (0, 3 or 5μg/l) for 48 hours. (f) mRNA and protein levels of Notch-1 in two parental LAD cell lines treated with 5 μg/l DTX for 0, 3, 5, or 7 days. Scale bar = 50 μm. *P < 0.05 and **P < 0.01. LAD, lung adenocarcinoma; mRNA, microRNA.