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. 2016 Oct 11;5(10):e375. doi: 10.1038/mtna.2016.82

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Copyright © 2016 Official journal of the American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Inhibition of Notch-1 sensitizes LAD to DTX in vivo. SPC-A1/DTX and H1299/DTX cells stably interfered Notch-1 expression were subcutaneously explanted into nude mice and DTX-resistant LAD cell stable transfected with sh-control was used as normalized. (a) The xenograft tumors were obtained and measured. (b) The tumor weight of xenograft tumors. (c) The values of tumor volume after transplantation. (d) The immunohistochemistry staining of ki-67, Notch-1 and proliferating cell nuclear antigen (PCNA) in tumor samples. (e) TUNEL staining in tumor samples. Scale bar = 50 μm. *P < 0.05 and **P < 0.01. LAD, lung adenocarcinoma; TUNEL, terminal deoxynucleotidyl transferase-mediated nick end labeling.