Table 3.
Multivariable predictors of any study medication dose reduction
| Characteristic | OR | 95% CI | χ2 |
|---|---|---|---|
| Serum creatinine (per mg/dL) | 2.38 | 2.01–2.82 | 101.8 |
| Age (per 10 years above 60) | 1.27 | 1.19–1.36 | 53.6 |
| Region (reference = Central Europe) | 49.9 | ||
| North America | 1.77 | 1.46–2.14 | |
| Latin America | 1.20 | 1.04–1.38 | |
| Western Europe and other | 1.25 | 1.11–1.42 | |
| Asia‐Pacific | 0.90 | 0.78–1.04 | |
| NT‐proBNP (per log) | 1.16 | 1.11–1.22 | 38.6 |
| SBP (per 10 mmHg decrease below 120) | 1.21 | 1.13–1.29 | 34.1 |
| Heart rate (per 10 b.p.m.) | 1.09 | 1.05–1.14 | 20.6 |
| NYHA class (reference = Class II) | 12.6 | ||
| I | 0.82 | 0.66–1.03 | |
| III | 1.15 | 1.03–1.29 | |
| IV | 0.68 | 0.39–1.20 | |
| History of MI | 1.17 | 1.07–1.29 | 11.2 |
| History of DM | 1.17 | 1.07–1.29 | 11.0 |
| Beta‐blocker | 0.76 | 0.64–0.91 | 9.4 |
| Sex: female | 1.17 | 1.04–1.32 | 7.3 |
CI, confidence interval; DM, diabetes mellitus; OR, odds ratio; MI, myocardial infarction; SBP, systolic blood pressure.