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Mutability landscape data derived from van der Meer et al.31 A) Mutational effects on 4‐OT's tautomerase activity, plotted versus the mutational effects on 4‐OT's promiscuous Michael‐type addition activity. B) Mutational effects on 4‐OT's enantioselectivity in the Michael‐type addition reaction, plotted versus the mutational effects on 4‐OT's activity in the Michael‐type addition reaction.
