Table 3.
Association of replicated single nucleotide polymorphisms (SNPs) with bipolar disorder in the Latino cohort
| Marker | Position | Gene | Previous GWAS association | Allele | RAF | BD narrow | BD broad | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P perm | OR | 95% CI | P perm | ||||||
| rs7556462 | 1p31.3 | NFIA | Lee et al.36 (BDa) | T | 0.42 | 1.33 | 0.97–1.84 | 0.040 | 1.27 | 0.95–1.70 | 0.370 |
| rs6703335 | 1q43 | SDCCAG8 | Schizophrenia PGC28 (SCa)Sleiman et al.41 (SC, SA, BDb) | G | 0.63 | 1.46 | 1.02–2.09 | 6.00E −04 | 1.40 | 1.02–1.92 | 4.00E −04 |
| rs6444931 | 3q26.2 | MIR6828−SLC7A14 | Wang et al.23 (BD, SCa) | G | 0.11 | 1.61 | 0.89–2.90 | 0.044 | 1.23 | 0.76–2.00 | 0.162 |
| rs514636 | 3q27.1 | LAMP3 | Jiang & Zhang25 (BDa) | G | 0.12 | 1.63 | 0.98–2.70 | 0.026 | 2.17 | 1.33–3.56 | 0.023 |
| rs230529 | 4q24 | NFKB1 | Liou et al.33 (SCc) | T | 0.55 | 1.28 | 0.95–1.74 | 3.00E −04 | 1.17 | 0.89–1.55 | 0.013 |
| rs9378249 | 6p21.33 | HLA‐B | Jiang & Zhang25 (BDa) | A | 0.96 | 2.33 | 1.19–4.59 | 0.022 | 2.07 | 1.09–3.92 | 0.073 |
| rs10949808 | 7q36.3 | SHH−LINC01006 | Wang et al.23 (BD, SCa) | T | 0.52 | 1.27 | 0.91–1.78 | 0.022 | 1.25 | 0.94–1.67 | 0.011 |
| rs11191580 | 10q24.33 | NT5C2 | Schizophrenia PGC28 (SCa)Bergen et al.34 (SCa)Cross‐Disorder Group PGC38 (combineda , d) | C | 0.15 | 0.73 | 0.47–1.13 | 0.040 | 0.86 | 0.58–1.26 | 0.078 |
Previous genome‐wide association studies (GWASs) indicate the initial citation(s) of the association, clinical phenotype(s), and ancestry populations tested. Minor allele (based on TOP strand), minor allele frequency (MAF), odds ratio (OR), permuted P‐value based on 10 000 permutation, and direction of association are listed for replicated a priori GWAS SNPs under narrow (bipolar disorder type I) and broad (bipolar disorder type I/II, schizoaffective bipolar type, or bipolar disorder not otherwise specified) bipolar phenotypes. BD, bipolar disorder; CI, confidence interval; OR, odds ratio; RAF, risk allele frequency; NFIA, nuclear factor I A; SDCCAG8, serologically defined colon cancer antigen 8; MIR6828, microRNA 6828; SLC7A14, solute carrier family 7 member 14; LAMP3, lysosomal associated membrane protein 3; NFKB1, nuclear factor kappa B subunit 1; HLA‐B, major histocompatibility complex, class I, B; SHH, sonic hedgehog; LINC01006, long intergenic non‐protein coding RNA 01006; NT5C2, 5′‐nucleotidase, cytosolic II; SC, schizophrenia; SA, schizoaffective disorder; PGC, Psychiatric Genome‐wide Association Study Consortium.
Study populations: aEuropean; bEuropean, African American, Asian, other, and unknown ancestry; cHan Chinese; dCombined=autism spectrum disorder, attention‐deficit hyperactivity disorder, BD, major depressive disorder, and SC.
P‐value<.05 denoted in bold.