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. 2016 Oct 27;473(21):3997–4009. doi: 10.1042/BCJ20160696

Figure 1. The classical and coproporphyrin-dependent pathways of haem synthesis.

Figure 1.

This is a depiction of haem synthesis in a hypothetical ancestral organism in which the oxidation of coproporphyrinogen III to coproporphyrin III (blue) and the classical route, involving a protoporphyrin IX intermediate (red), takes place. HemQ is hypothesised to generate ROS, which, in turn, are hypothesised to have an impact on protoporphyrinogen IX oxidation to a greater extent than coproporphyrinogen III oxidation.