A model for TRR-NFκB function in cell competition, incorporating data from both competitive contexts. See text for full description.We propose that in both Minute- and Myc-induced competitive contexts, loser cells are eliminated through a signaling pathway mediated by Spz,TRRs, and NFκB function. Context-and/or genetic-dependent interactions that cause Rel activation trigger expression of Hid, whereas those activating Dif and Dorsal trigger expression of Rpr. Apoptosis is the ultimate fate of both loser populations. Red denotes genes required for Myc-induced competition, blue indicates those required for competition in M/+ mosaics, and orange denotes shared requirements.