Fig. 2.

A metabolic function for fly huntingtin (htt). a and b Trait association to htt genotype in the DGRP. Data are as in Fig. 1a-b, except that an intronic indel in htt is analyzed. c and d Validation of htt function in laboratory strains. c Each trace reports survival of a strain expressing a GAL4 activator under the daughterless promoter and harboring an htt RNAi construct (RNAi) or no RNAi transgene (control), pre-treated for 10 days on the indicated diet and then switched to acute starvation media. d Each column reports body mass per fly of the indicated strain, with genotypes as in c. (n = 5 populations of 15 flies per condition). Symbols and abbreviations are as in Fig. 1. For strain details see Additional file 1: Table S6