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. 2016 Nov 4;17:867. doi: 10.1186/s12864-016-3137-9

Table 1.

Variants associated with metabolic traits

Screena Phenotype(s)b Testb Chrc Positionc Genec % Vard p e FDRf
MAF ≥ 5 % starvation resistance genotype 2L 13967604 nimB3 18 % 3.70E-13 0 %
MAF ≥ 5 % triglycerides genotype 3R 14072066 14-3-3 ε 20 % 1.29E-14 10 %
MAF ≥ 5 % starvation resistance and triglycerides on AL SMAT 3L 11418293 CG7560 8 % 8.88E-16 0 %
MAF ≥ 5 % starvation resistance and triglycerides on AL SMAT 2R 16952034 Cht12 6 % 6.18E-11 10 %
MAF ≥ 5 % starvation resistance and mass on AL SMAT 3R 19635620 EIF4G2 8 % 1.71E-13 10 %
MAF ≥ 5 % starvation resistance and mass on AL SMAT 3R 24549344 htt 12 % 2.78E-12 10 %
MAF ≥ 5 % starvation resistance and mass on DR SMAT X 6152605 schlank 3 % 4.44E-16 0 %
MAF ≥ 5 % starvation resistance and mass on DR SMAT X 6152619 schlank 3 % 4.44E-16 0 %
MAF ≥ 5 % starvation resistance and mass on DR SMAT X 6152558 schlank 2 % 6.66E-16 0 %
MAF ≥ 5 % starvation resistance and mass on DR SMAT X 6152586 schlank 2 % 8.88E-16 0 %
MAF ≥ 25 % body mass genotype X 12430723 CG43921 15 % 3.84E-13 0 %
MAF ≥ 25 % glucose interaction 3R 8877613 pic 4 % 5.94E-3 7 %
MAF ≥ 25 % glucose interaction 3R 8877592 pic 4 % 6.72E-3 7 %
MAF ≥ 25 % glucose interaction 3R 8877227 CG7966 5 % 6.75E-3 7 %
MAF ≥ 25 % glucose interaction 3R 8877378 CG7966 5 % 8.69E-3 8 %
MAF ≥ 25 % starvation genotype 2L 13967604 nimB3 18 % 3.70E-13 0 %
MAF ≥ 25 % starvation resistance and mass on DR SMAT X 8903670 rdgA 15 % 1.27E-08 10 %
MAF ≥ 25 % starvation resistance and triglycerides on DR SMAT 3R 4279209 CG43462 8 % 1.29E-09 10 %

aResults from association scans across markers meeting the indicated criterion. For results from the scaled multiple-phenotype association test (SMAT) applied to variants at frequency of ≥5 %, only human disease orthologs were tested

bThe single phenotype whose measurements in animals reared on both diets were tested in a linear model with terms for diet, genotype, and the interaction between the two; or the pair of phenotypes whose measurements in animals reared on the indicated diet were tested via SMAT. DR, dietary restriction; AL, ad libitum

cChromosome segment, position (in D. melanogaster genome version R5 coordinates), and gene in which the associating marker lay

dPercent phenotypic variation explained by the indicated polymorphism. For pairs of phenotypes, the value reports results for the single phenotype with the highest % variance explained

eNominal association p-value

fFalse discovery rate at the association p-value according to permutation analysis