Table 1.
Screena | Phenotype(s)b | Testb | Chrc | Positionc | Genec | % Vard | p e | FDRf |
---|---|---|---|---|---|---|---|---|
MAF ≥ 5 % | starvation resistance | genotype | 2L | 13967604 | nimB3 | 18 % | 3.70E-13 | 0 % |
MAF ≥ 5 % | triglycerides | genotype | 3R | 14072066 | 14-3-3 ε | 20 % | 1.29E-14 | 10 % |
MAF ≥ 5 % | starvation resistance and triglycerides on AL | SMAT | 3L | 11418293 | CG7560 | 8 % | 8.88E-16 | 0 % |
MAF ≥ 5 % | starvation resistance and triglycerides on AL | SMAT | 2R | 16952034 | Cht12 | 6 % | 6.18E-11 | 10 % |
MAF ≥ 5 % | starvation resistance and mass on AL | SMAT | 3R | 19635620 | EIF4G2 | 8 % | 1.71E-13 | 10 % |
MAF ≥ 5 % | starvation resistance and mass on AL | SMAT | 3R | 24549344 | htt | 12 % | 2.78E-12 | 10 % |
MAF ≥ 5 % | starvation resistance and mass on DR | SMAT | X | 6152605 | schlank | 3 % | 4.44E-16 | 0 % |
MAF ≥ 5 % | starvation resistance and mass on DR | SMAT | X | 6152619 | schlank | 3 % | 4.44E-16 | 0 % |
MAF ≥ 5 % | starvation resistance and mass on DR | SMAT | X | 6152558 | schlank | 2 % | 6.66E-16 | 0 % |
MAF ≥ 5 % | starvation resistance and mass on DR | SMAT | X | 6152586 | schlank | 2 % | 8.88E-16 | 0 % |
MAF ≥ 25 % | body mass | genotype | X | 12430723 | CG43921 | 15 % | 3.84E-13 | 0 % |
MAF ≥ 25 % | glucose | interaction | 3R | 8877613 | pic | 4 % | 5.94E-3 | 7 % |
MAF ≥ 25 % | glucose | interaction | 3R | 8877592 | pic | 4 % | 6.72E-3 | 7 % |
MAF ≥ 25 % | glucose | interaction | 3R | 8877227 | CG7966 | 5 % | 6.75E-3 | 7 % |
MAF ≥ 25 % | glucose | interaction | 3R | 8877378 | CG7966 | 5 % | 8.69E-3 | 8 % |
MAF ≥ 25 % | starvation | genotype | 2L | 13967604 | nimB3 | 18 % | 3.70E-13 | 0 % |
MAF ≥ 25 % | starvation resistance and mass on DR | SMAT | X | 8903670 | rdgA | 15 % | 1.27E-08 | 10 % |
MAF ≥ 25 % | starvation resistance and triglycerides on DR | SMAT | 3R | 4279209 | CG43462 | 8 % | 1.29E-09 | 10 % |
aResults from association scans across markers meeting the indicated criterion. For results from the scaled multiple-phenotype association test (SMAT) applied to variants at frequency of ≥5 %, only human disease orthologs were tested
bThe single phenotype whose measurements in animals reared on both diets were tested in a linear model with terms for diet, genotype, and the interaction between the two; or the pair of phenotypes whose measurements in animals reared on the indicated diet were tested via SMAT. DR, dietary restriction; AL, ad libitum
cChromosome segment, position (in D. melanogaster genome version R5 coordinates), and gene in which the associating marker lay
dPercent phenotypic variation explained by the indicated polymorphism. For pairs of phenotypes, the value reports results for the single phenotype with the highest % variance explained
eNominal association p-value
fFalse discovery rate at the association p-value according to permutation analysis