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. 2016 Nov 4;16:841. doi: 10.1186/s12885-016-2864-2

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Association of individual genes in the prognostic signatures with prognosis in breast cancer microarray sets. The association with prognosis of the expression of individual genes in the good (a) and poor (b) prognosis signatures was analyzed using Cox proportional hazards modeling. Figures demonstrate 95 % confidence interval of the hazard ratio for the standardized log2 mRNA expression of indicated genes in a univariate (dark colors) or multivariate (bright colors) model. In the latter case the aggregated value of the poor prognosis signature (a) or good prognosis signature (b) was used as additional variable in the model