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. 2016 Jul 7;56(Suppl Suppl 7):S132–S142. doi: 10.1002/jcph.669

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© 2016, The Authors. The Journal of Clinical Pharmacology Published by Wiley Periodicals, Inc. on behalf of American College of Clinical Pharmacology

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Schematic representation of the transporter pathways included in the rosuvastatin full PBPK model. This schematic depicts the mechanistic permeability‐limited models included in this study. The Advanced Dissolution, Absorption, and Metabolism (ADAM) model, which represents the gastrointestinal tract and the permeability‐limited liver (PerL) model have been previously implemented,34 whereas the mechanistic kidney model (Mech KiM) was added in the extended rosuvastatin model used in this study in order to mechanistically account for the renal component of rosuvastatin disposition and the role of renal transporters, OAT3 and BCRP.