Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Details of the Clinical OATP1B1 Polymorphism Study Design by Pasanen et al13 Used for Performance Verification of the OATP1B1 Phenotype Component of the Rosuvastatin PBPK Model*
| OATP1B1 | Number of | Age Range | Proportion |
|---|---|---|---|
| Genotype | Subjects | (Years) | Female |
| c.521TT | 16 | 20‐23 | 0.5 |
| c.521TC | 12 | 21‐24 | 0.42 |
| c.521CC | 4 | 20‐23 | 0.25 |
*A single oral dose of 10 mg rosuvastatin was administered.
