Table 3.

Outcome of Simulations to Determine the Number of Poor Transporter (PT) and Intermediate Transporter (IT) Subjects Required to Reach 80% Power to Discriminate the AUC of Rosuvastatin From Extensive Transporter Phenotype Carriers Tested Under Various Conditions

Condition Tested in the	Number of	Number of
PBPK Model	PT Subjects	IT Subjects
No colinearity between OATP1B1 and OATP1B3 assumed (scenario 1)	10	45
Colinearity between OATP1B1 and OATP1B3 assumed (scenario 2)	7	40
Setting all CV values for OATPs to 0 (scenario 3)	5	19
Setting all transporter CV values to 0 (scenario 4)	3	17