Figure 6.

Proposed mode of action of [3](PF₆)₂. Treatment with concentrations above the CAC leads to lipid–protein extraction, and eventually to necrotic cell death. Treating the cells with concentrations below the CAC leads to insertion of the compound in the cell membrane, followed by a time‐dependent internalization. A significant photon‐enhanced effect was only observed after 24 h incubation, that is, after internalization of [3]²⁺, and thus, when the resulting active complex [1]²⁺ could interact with an (unknown) intracellular target.