Table 2.
Half maximal inhibitory concentration (IC50) values for susceptible and resistant C. albicans and C. glabrata isolates used in the study.
| Fks mutation | IC50 (ng/ml)a | ||||
|---|---|---|---|---|---|
| Strain | Species | Fks1p | Fks2p | MCF | CD101 |
| DPL1002 | C. albicans | WT | — | 17.7 | 14.3 |
| DPL18 | C. albicans | F641S | — | 1782.0 | 347.4 |
| DPL20 | C. albicans | S645P | — | 2555.8 | 2641.4 |
| DPL22 | C. albicans | S645P/S | — | 245.5 | 30.5 |
| DPL50 | C. glabrata | WT | WT | 0.5 | 2.6 |
| DPL23 | C. glabrata | WT | F659del | > 10 000 | > 10 000 |
| DPL30 | C. glabrata | WT | S663P | 6772.3 | > 10 000 |
a
IC50s are the arithmetic mean of three replicate determinations.