Table 2.
LINE1 hypomethylation at birth and at 5 years for the DHA and control group
| Subgroup | DHA group mean (SD) | Control group mean (SD) | Treatment effect DHA-control adjusteda (95% CI) | P value, adjusteda |
|---|---|---|---|---|
| Birth | 1.47 (0.57)b | 1.43 (0.45) | 0.04 (−0.02, 0.10) | 0.211 |
| 5 years | 0.99 (0.15) | 0.99 (0.16) | 0.00 (−0.02, 0.03) | 0.706 |
| Birth, female | 1.56 (0.64) | 1.50 (0.48) | 0.06 (−0.04, 0.15) | 0.229 |
| Birth, male | 1.39 (0.49) | 1.36 (0.42) | 0.03 (−0.06, 0.11) | 0.583 |
| 5 years, female | 1.04 (0.16) | 1.03 (0.17) | 0.01 (−0.03, 0.04) | 0.655 |
| 5 years, male | 0.95 (0.13) | 0.95 (0.15) | 0.00 (−0.03, 0.03) | 0.837 |
All children who had any global DNA methylation data were used for this analysis; 522 children had data at birth and 5 years, 469 had data at birth only, 141 had data at 5 years only
aAdjustment was made for centre, parity and gender
bLINE1 methylation values are expressed as relative hypomethylation values compared to a reference sample