Table 3.
Differentially methylated regions between the DHA-supplemented and control group at birth
| hg19 coordinates | No. of probes | Size (bp) | Gene | Genomic location | Min P valuea | Max beta diff (DHA-control)b | VMR overlap | |
|---|---|---|---|---|---|---|---|---|
| 1 | chr3:138152837-138153763 | 12 | 926 | ESYT3 | TSS1500,TSS200,1stExon,5′UTR | 5.75E−15 | −0.045 | Y |
| 2 | chr12:132293329-132293702 | 5 | 373 | Intergenic | 1.12E−07 | −0.026 | Y | |
| 3 | chr15:34610829-34611069 | 4 | 240 | SLC12A6 | Body,1stExon,5′UTR,TSS200 | 4.99E−06 | −0.011 | Y |
| 4 | chr3:42306150-42307193 | 10 | 1043 | CCK | 5′UTR,1stExon,TSS200,TSS1500 | 6.05E−06 | −0.012 | Y |
| 5 | chr7:1882776-1883876 | 9 | 1100 | MAD1L1 | Body | 8.75E−06 | 0.023 | Y |
| 6 | chr2:48844728−48845068 | 8 | 340 | GTF2A1L, STON1 | TSS1500,Body,TSS200,1stExon,5′UTR | 8.75E−06 | −0.019 | Y |
| 7 | chr6:166876490-166877038 | 7 | 548 | RPS6KA2 | Body | 8.75E−06 | 0.022 | Y |
| 8 | chr8:59058254-59058585 | 3 | 331 | FAM110B | 5′UTR | 9.79E−06 | −0.009 | N |
| 9 | chr10:134221633-134222453 | 6 | 820 | PWWP2B | 3′UTR,Body | 1.10E−05 | −0.033 | Y |
| 10 | chr3:42201314-42201898 | 6 | 584 | TRAK1 | TSS1500,Body,TSS200,1stExon | 2.11E−05 | −0.015 | N |
| 11 | chr6:150346721-150347053 | 10 | 332 | RAET1L | TSS200,TSS1500 | 5.41E−05 | −0.009 | Y |
| 12 | chr12:7781004-7781431 | 5 | 427 | Intergenic | 2.15E−04 | −0.044 | Y | |
| 13 | chr6:1619162-1619687 | 3 | 525 | Intergenic | 2.62E−04 | −0.012 | N | |
| 14 | chr8:117950244-117950504 | 7 | 260 | C8orf85 | TSS1500,TSS200,1stExon,5′UTR | 4.08E−04 | −0.01 | N |
| 15 | chr4:62382932-62383240 | 4 | 308 | LPHN3 | Body | 6.20E−04 | −0.019 | N |
| 16 | chr4:1107202-1107259 | 2 | 57 | RNF212 | 1stExon,5′UTR | 6.45E−04 | −0.01 | N |
| 17 | chr17:75446431-75446661 | 6 | 230 | SEPT9 | TSS200,Body,1stExon,5′UTR | 7.94E−04 | −0.013 | N |
| 18 | chr6:31549929-31550090 | 2 | 161 | LTB | Body,1stExon | 8.92E−04 | −0.008 | N |
| 19 | chr22:32599511-32599516 | 2 | 5 | RFPL2 | TSS200,5′UTR,TSS1500 | 9.17E−04 | −0.037 | Y |
| 20 | chr20:13620031-13620048 | 2 | 17 | TASP1 | TSS1500 | 9.61E−04 | 0.012 | N |
| 21 | chr1:156261200-156261207 | 2 | 7 | TMEM79 | Body | 9.77E−04 | 0.01 | N |
Abbreviations: DMR differentially methylated region, VMR variable methylated region, TSS1500 1500 base pairs from the transcription start site, TSS200 200 base pairs from the transcription start site, 5′UTR 5′ untranslated region, 3′UTR 3′ untranslated region
aSmallest P value for a probe in the DMR
bLargest DNA methylation (beta value) difference between the DHA and control group for a probe within the DMR