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. 2016 Nov 4;16:846. doi: 10.1186/s12885-016-2865-1

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Effects of silencing LPA1-3 on ovarian cancer cells’ response for LPA-induced invasion. a SK-OV3 and HEY cells were transduced with control or LPAR1-3 shRNAs and then analyzed for cell invasion with or without 20 μM LPA contained in the underwells. Results are presented as fold increase of cell invasion (OD600 LPA-induced cell invasion /OD600 base cell invasion). Data are means SE. n = 3. Differences between groups were assessed using Student t test. b We lentivirally overexpressed LPAR1 in I IGROV1, TOV21G and OVCAR3 lines. Enforced LPAR1 expression was unable to render non-metastatic IGROV1, TOV21G and OVCAR3 cells responding to LPA for cell invasion