Table 1.
Univariate analysis of risk factors for infection-related death in 127 patients with infections caused by CRE
| Characteristics | Total (n = 127) | Survivors (n = 83) | Deaths (n = 44) | RR (95 % CI) | P |
|---|---|---|---|---|---|
| Patient related | |||||
| Age (years) (SD) | 55.7(18) | ||||
| Age over 60 (%) | 57(44.9) | 32(38.5) | 25(56.8) | 1.29(0.99–1.70) | 0.03 |
| Male (%) | 88(69.3) | 59(71.0) | 29(65.9) | 0.91(0.68–1.22) | 0.34 |
| ICU (%) | 98(77.2) | 60(72.3) | 38(86.4) | 1.29(1.01–1.65) | 0.054 |
| Comorbidities (%) | 97(76.4) | 67(73.6) | 30(83.3) | 1.39(1.10–1.75) | 0.01 |
| =1 | 23(18.1) | 19(22.9) | 4(9,0) | 0.74(0.58–0.94) | 0.04 |
| =2 | 32(25.2) | 17(20.5) | 15(34.0) | 1.30(0.92–1.85) | 0.07 |
| 3 or more | 42(33.0) | 22(26.5) | 20(45.4) | 1.37(0.99–1.88) | 0.02 |
| Surgery (%) | 59(46.5) | 41(49.4) | 18(40.9) | 0.88(0.69–1.14) | 0.23 |
| Dialyses (%) | 45(35.4) | 18(21.7) | 27(61.4) | 1.98(1.36–2.88) | 0.0001 |
| Previous colonization (%) | 76(59.8) | 50(60.2) | 26(59.0) | 0.98(0.75–1.27) | 0.52 |
| Infection (%) | |||||
| Pneumonia | 52(41.0) | 25(30.1) | 27(61.4) | 1.60(1.18–2.18) | 0.0006 |
| UTI | 51(40.2) | 39(47.0) | 12(27.3) | 0.75(0.59–0.96) | 0.02 |
| Bloodstream | 9(7.0) | 7(8.4) | 2(4.5) | 0.82(0.56–1.20) | 0.33 |
| Tissue | 13(10.2) | 10(12.0) | 3(6.8) | 0.83(0.59–1.15) | 0.27 |
| Abdominal | 2(1.6) | 2(2.4) | 0 | 0.64(0.56–0.73) | 0.42 |
| Sepsis | 28(22.0) | 27(32.5) | 1(2.3) | 0.58(0.48–0.70) | 0.0001 |
| Severe sepsis | 21(16.5) | 17(20.5) | 4(9.0) | 0.76(0.59–0.99) | 0.07 |
| Shock | 63(49.6) | 25(30.1) | 38(86.4) | 2.28(1.66–3.12) | 0.0001 |
| Infection site (%) | |||||
| Lungs | 46(36.2) | 23(27.7) | 23(52.7) | 1.48(1.07–2.03) | 0.005 |
| Urine | 51(40.2) | 39(47.0) | 12(27.3) | 0.75(0.59–0.96) | 0.02 |
| Blood | 21(16.5) | 11(13.2) | 10(22.7) | 1.29(0.84–1.99) | 0.13 |
| Tissue | 11 (8.7) | 7(8.4) | 4(9.1) | 1.02(0.64–1.64) | 0.56 |
| Others | 8(8.0) | 8(9.6) | 0 | 0.63(0.54–0.72) | 0.02 |
| Pathogen (%) | |||||
| K. pneumoniae | 113(89.0) | 74(89.2) | 39(88.6) | 0.98(0.64–1.48) | 0.57 |
| Polymyxin-resistant | 27(21.3) | 17(20.5) | 10(22.7) | 1.04(0.75–1.44) | 0.46 |
| Polymicrobial | 55(43.3) | 34(41.0) | 21(47.7) | 1.10(0.84–1.42) | 0.29 |
| Co-infection A. baumannii | 36(28.3) | 22(26.5) | 14(31.8) | 1.09(0.81–1.47) | 0.33 |
| Co-infection P. aeruginosa | 13(10.2) | 7(8.4) | 6 (13.6) | 1.23(0.73–2.08) | 0.26 |
| blaKPC+ | 96(75.6) | 68(81.9) | 28(63.6) | 0.68(0.46–1.00) | 0.02 |
CRE carbapenem-resistant Enterobacteriaceae, RR relative risk, CI confidence interval, SD Standard deviation, LOS length of stay, IQR interquartile range, UTI urinary tract infection