Table 1. Characteristics of 25 reported patients with a Zika virus infection, worldwide, 1956–2016.

First author of publication (year)	Patient’s characteristic
	Age (years)	Sex	Place of origin	Probable place of Zika virus infection	Year of exposure to the virus	Length of exposure period (days)	Possible time to symptom onset, range (days)	Possible time to seroconversion, range (days)	Possible time to viral clearance from serum, range (days)a
Bearcroft (1956)28	34	Male	Europe	Nigeria	ND	< 1b	3–4	4–9	> 6c
Chen (2016)29	55	Male	United States	Costa Rica	2015	8	3–12	< 39	ND
Duffy (2009)4	ND	Female	United States	Yap Islands	2007	13	7–21	< 34	ND
Fonseca (2014)30	ND	Female	Canada	Thailand	2013	16	1–18	< 24d	26–28
Foy (2011)31	36	Male	United States	Senegal	2008	24	5–30	< 33	< 33e
	27	Male	United States	Senegal	2008	24	4–29	< 33	< 33e
	ND	Female	United States	United Statesf	2008	7	3–11	15–34	< 16e
Ginier (2016)32	51	Female	Switzerland	El Salvador, Guatemala	2015	14	3–18	< 24	> 23
Gyurech (2016)33	44	Female	Switzerland	Brazil	2015	1	4–17	19–23	< 23
Korhonen (2016)34	37	Male	Finland	Maldives	2015	183	1–185	ND	< 191g
Kutsuna (2014)35	30–35	Female	Japan	Bora Bora	2013–2014	10	5–16	< 21	< 21h
Kwong (2013)36	52	Female	Australia	Indonesia	ND	9	0–10	ND	13–24
Leung (2015)37	27	Male	Australia	Indonesia	ND	6i	2–9	ND	< 14j
Maria (2016)38	60–69	Female	France	Martinique	2015	22	1–24	< 28	ND
	20–29	Male	France	Brazil	2015–2016	8	0–9	< 17	ND
	50–59	Male	France	Colombia	2015–2016	29	0–30	31–37	NDk
Shinohara (2016)39	40–45	Male	Japan	Thailand	2014	7	1–9	10–14	> 10d
Simpson (1964)40	28	Male	Europe	Uganda	ND	76	0–77	< 78	> 2c
Summers (2015)41	48	Male	United States	Bolivia (Plurinational State of), Chile, Easter Island, Ecuador, French Polynesia, Hawaii, Peru	2013	34	0–35	< 45	ND
Tappe (2015)42	45	Female	Germany	Malaysia	2014	22	5–28	29–33	< 30
Tappe (2014)43	50–55	Male	Germany	Thailand	2013	12	0–12	< 22	< 22
Wæhre (2014)44	31	Female	Norway	Tahiti	2013	15	0–16	20–52	20–52e
Zammarchi (2015)45	60–65	Male	Italy	Brazil	2015	12	0–13	< 16	< 16
Zammarchi (2015)46	30–35	Female	Italy	French Polynesia	2013–2014	19	0–20	22–58	> 22
	30–35	Male	Italy	French Polynesia	2013–2014	19	0–20	22–56	< 23

ND: not determined.

^a Viral clearance was defined as no detectable virus in blood.

^b Inoculation of a volunteer with the Zika virus.

^c Viral shedding determined from mouse inoculation.

^d An equivocal test result was counted as a positive result.

^e Serum tested positive for the virus on polymerase chain reaction (PCR) testing but was negative on culture.

^f Probable sexual transmission.

^g Serum tested negative for the virus on PCR testing but urine tested positive on PCR testing at a later visit.

^h Serum tested negative for the virus on PCR testing but urine tested positive on PCR testing.

ⁱ Possible transmission from a monkey bite or mosquito.

^j Serum taken from, and a swab of, the site of the monkey bite tested negative for the virus on PCR testing but a nasopharyngeal swab tested positive on PCR testing.

^k No sera tested; plasma and urine tested positive for the virus on PCR testing; at a later visit, plasma tested negative on PCR testing and urine and saliva tested positive on PCR testing.