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. Author manuscript; available in PMC: 2017 Sep 28.
Published in final edited form as: J Am Chem Soc. 2016 Sep 15;138(38):12364–12367. doi: 10.1021/jacs.6b08902

Scheme 2.

Scheme 2

Synthesis of Fragment A via anti-diastereo- and enantioselective alcohol C-H tert-(hydroxy)prenylation.a

aYields are of material isolated by silica gel chromatography. Enantioselectivity was determined by chiral stationary phase HPLC analysis. See Supporting Information for further experimental details.