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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Reprod Toxicol. 2016 Jun 16;65:414–424. doi: 10.1016/j.reprotox.2016.06.009

Table 2. Protein spots with altered abundances that were ranked of greatest import within the PLS-DA model, VIP values (≥1.75; p<0.05).

Numbers in red represent decreased abundance and the numbers in blue represent increased abundance of proteins in 6 month old offspring previously developmentally exposed to cigarette smoke (GD1-PD21), as compared to the Sham group. Corresponds to Figure 1.

Spot Number GI Number Abbreviation1 Protein Identification VIP Percent Change
1 24691 PRSS2 Anionic trypsin-1 1.92 −26
3 1174637 VCP Transitional endoplasmic reticulum ATPase 2.00 −21
4 341941239 P4HB Protein disulfide-isomerase 2.25 −19
5 51702252 HSPD1 60 kDa heat shock protein, mitochondrial 2.13 −35
7 225913 Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing) 1.78 −37
11 11669 ALDH2 Aldehyde dehydrogenase, mitochondrial 1.87 −29
17 15516 HSP90AB1 Heat shock protein HSP 90-beta 2.02 −32
24 14085 FAH Fumarylacetoacetase 1.92 −36
2 341942170 RDX Radixin 2.07 95
6 16691 KRT8 Keratin, type II cytoskeletal 8 1.77
8 14661 GLUD1 Glutamate dehydrogenase 1, mitochondrial 1.98 61
9 Q03265 ATP5A1 ATP synthase subunit alpha, mitochondrial 1.80 21
10 12116 BHMT Betaine-homocysteine S-methyltransferase 1 1.89 47
12 20342 SELENBP1 Selenium-binding protein 2 1.97 80
13 11657 ALB Serum albumin 1.96 46
14 29443 AHCY Adenosylhomocysteinase 2.18 80
15 52815 Probable D-lactate dehydrogenase, mitochondrial 1.88 53
16 11465 F-actin Actin, cytoplasmic 2 1.84 34
18 19733 RGN Regucalcin 1.89 34
19 25659 KHK Ketohexokinase 1.99 39
20 14121 FBP1 Fructose-1,6-bisphosphatase 1 2.20 43
21 56357 Isovaleryl-CoA dehydrogenase, mitochondrial 1.93 86
22 13637776 ENO1 Alpha-enolase 1.78 47
23 11846 Arginase-1 1.82 51
25 14555 Glycerol-3-phosphate dehydrogenase (NAD+), cytoplasmic 2.01 69
26 107766 3-hydroxyanhranilate 3,4-dioxygenase 1.99 41
27 63938 3-hydroxyisobutyrate dehydrogenase, mitochondrial 2.25 39
28 Not identified 1.81 23
29 3122065 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 1.95 55
30 107766 3-hydroxyanhranilate 3,4-dioxygenase 1.86 42
31 66302 Regulator of microtubule dynamics protein 1 1.85 120
32 3219774 PRDX6 Peroxiredoxin-6 1.98 30
33 14862 GSTM5 Glutathione S-transferase Mu 1 2.27 15
34 18477 PRDX1 Peroxiredoxin-1 2.14 37
35 11430 ACOX1 Peroxisomal acyl-coenzyme A oxidase 1 2.26 95
36 20042 40S ribosomal protein S12 1.75 49
1

Denotes abbreviation used in Figure 4. VIP (Variable Importance in Projection); GI Number (NCBI protein sequence GenInfo Identifier).