Study Design
100 patients had brain metastases secondary to gynecologic cancer. For 84 patients there was no brain specimen available, 16 patients had pathologic brain tissue specimens available through our pathology department and were used for further molecular analyses. Of the 16 patients, 7 had endometrial cancer, 5 had ovarian, and 4 had cervical cancer. The sixteen cases of brain metastases were matched to 48 controls matched for type of cancer, age, race, stage, and year of treatment. For 5 of the 16 patients, matched brain and primary tissue samples were also available.