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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Pharm Res. 2016 Jun 10;33(10):2400–2410. doi: 10.1007/s11095-016-1963-8

Table 1.

Characterization of Comb and 5 %, 10%, and 25% CANF-Comb

Polymer Mna Đa Size (nm)b ζ-Potential (mV) # of CANF /nanoparticlec # of DOTA/nanoparticlec 64Cu radiolabeling specific activity (GBq/nmol) Log P
Comb 220,000 1.25 22 −35 ± 2 N/A 105 4.5 ± 0.8 −2.5 ± 0.3
5% CANF-Comb 166,000 1.80 17 2.6 ± 3.7 7 105 1.4 ± 0.5 −2.1 ± 0.2
10% CANF-Comb 205,000 1.20 17 1.9 ± 3.4 14 105 5.4 ± 1.2 −2.0 ± 0.3
25% CANF-Comb 205,000 1.20 16 −1.1 ± 1 35 105 3.7 ± 1.1 −1.3 ± 0.4
a

Determined by GPC in DMF, calibrated to PMMA standards (gmol−1), Đ = Mw/Mn.

b

Measured by dynamic light scattering.

c

Predicted incorporation