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Saquinavir accumulation in the LLC-PK1 cell model. Saquinavir accumulation in the LLC-PK1 MDR1 cells (gray bars) that over-express human P-gp was significantly lower than in the LLC-PK1 WT cells (black bars). Pluronic P85 significantly enhanced the cellular accumulation of saquinavir in the human P-gp over-expressing LLC-PK1 MDR1 cells (*p < 0.05). Results are expressed as mean ± SD (as percentage of wild-type control); n = 9.
