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. Author manuscript; available in PMC: 2016 Nov 4.
Published in final edited form as: Lancet HIV. 2014 Nov 24;1(3):e104–e111. doi: 10.1016/S2352-3018(14)00003-4
Criteria Definition

Population Adult HIV+ patients on ART in Africa
Interventions Any intervention to improve adherence to ART
Comparisons Standard of care or another intervention to improve adherence to ART
Outcomes Any measurement of adherence to ART
Study Design RCT with minimum 3 months of follow-up

Treatment definitions used for categorization of interventions in the network meta-analysis

Criteria Definition

Standard of Care
(SOC)
Usual standard of care
Enhanced SOC
(eSOC)
Usual standard of care, plus intensified adherence counseling
Alarm Participants received a pocket alarm device which they were to carry around at all times; this device was programmed to beep and flash twice a day to remind patients to take their medication
eSOC + alarm Enhanced SOC plus the pocket alarm device as described above
eSOC + calendar In addition to enhanced SOC, patients were given a treatment calendar containing educational messages about ART and adherence; patients were to record when they took their medication in the calendar
Daily SMS Daily text message sent to the patient’s cell phone (their own or one provided by the study) – with or without ability for patient to respond to care provider
Weekly SMS Weekly text message sent to the patient’s cell phone (their own or one provided by the study) – with or without ability for patient to respond to care provider
eSOC + weekly SMS Weekly text message sent to the patient’s cell phone (their own or one provided by the study) in addition to enhanced SOC
eSOC + treatment
supporter
Treatment supporter (chosen by individual or assigned by clinic) in addition to enhanced SOC
SOC + treatment
supporter
Treatment supporter (chosen by individual or assigned by clinic) in addition to SOC