Table III. Comparison of HIV CE-specific T Cell response breadth induced by gag pDNA and CE+gag pDNA booster vaccination regimens.
p24CE pDNA Prime | pDNA Booster Vaccine | Responses to Individual CE | No. of Positive CE per Animal | ||||||
---|---|---|---|---|---|---|---|---|---|
CE1 | CE2 | CE3 | CE4 | CE5 | CE6 | CE7 | |||
L862a | gag | + | + | + | + | 4 | |||
M166a | gag | + | + | + | 3 | ||||
M695a | gag | + | + | 2 | |||||
R279a | gag | + | + | + | + | 4 | |||
P314a | gag | + | + | + | 3 | ||||
P302a | gag | + | + | + | 3 | ||||
P307a | gag | + | + | + | 3 | ||||
P308a | gag | + | 1 | ||||||
R315a | gag | + | + | 2 | |||||
M437a | gag | + | 1 | ||||||
5698 | CE+gag | + | + | + | 3 | ||||
5699 | CE+gag | + | + | 2 | |||||
5700 | CE+gag | + | + | + | + | 4 | |||
5701 | CE+gag | + | + | + | + | + | + | 6 | |
5702 | CE+gag | + | + | + | + | + | 5 | ||
5703 | CE+gag | + | + | + | + | 4 |
Analysis of macaques vaccinated with p24CE prime/p55gag pDNA boost from Kulkarni et al. (21).