Fig. 5.

Task 5 (pre-cue delay: 0, 4, 8 s; cue duration: 0.4, 0.8, 1.2 s) percentage of inaccurate responses: (A) Percentage of inaccurate responses as a function of cue duration; the gt/+ mice made a significantly higher percentage of inaccurate responses than the WT mice specifically for trials with the briefest cue (p = 0.0002); and (B) percentage of inaccurate responses for the most demanding trials (8 s delay, 0.4 s cue duration), as a function of session-block, revealing a significantly higher percentage of inaccurate responses for mice on the Def diet relative to the Suf diet in session-block 1 (p = 0.041), whereas this pattern was reversed in session-block 2 (p = 0.006), before the groups converged in session-blocks 3 and 4. Abbreviations: WT Suf: wildtype mice fed a folate sufficient diet; WT Def: wildtype mice fed a folate deficient diet; gt/+ Suf: Mthfd1^gt/+ mice fed a folate sufficient diet; gt/+ Def: Mthfd1^gt/+ mice fed a folate deficient diet; gt/+: Mthfd1^gt/+ mice, WT: wildtype mice; Def: folate deficient diet, Suf: folate sufficient diet; *indicates significance ≤ 0.05. Data points are means ± SEM.