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. Author manuscript; available in PMC: 2016 Nov 4.
Published in final edited form as: Dev Biol. 2015 Oct 20;408(1):14–25. doi: 10.1016/j.ydbio.2015.10.012

Fig. 10.

Fig. 10

Schematic diagram of ependymoglial response to Injury. After injury to the spinal cord the membranes of the ependymal glial cells rostral and caudal to the injury site under go a rapid (7 h) depolarization and repolarization (24 h). This transient depolarization event is essential to activate genes expression cascades that are to initiate a pro-regenerative response. We identified one of these genes c-Fos, whose activation is inhibited by maintaining cells is a prolonged state of membrane depolarization, this subsequently inhibits regeneration.