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. Author manuscript; available in PMC: 2016 Nov 4.
Published in final edited form as: Dev Biol. 2015 Oct 20;408(1):14–25. doi: 10.1016/j.ydbio.2015.10.012

Fig. 4.

Fig. 4

Prolonged depolarization inhibits ependymoglial cell proliferation in response to spinal cord injury. Animals were injected with vehicle control of PBS (n=15) (A, A′, A″) or ivermectin (IVR) to induce prolonged depolarization of the membrane (n=16) (B, B′, B″) prior to spinal cord ablation. One day after injury animals were subjected to an intraperitoneal injection with BrdU and harvested for staining 24 h later. (A″, B″) Comparison of the percent of BrdU+ cells in IVR treated and control axolotls shows there are significantly fewer BrdU+ cells in IVR treated animals 48 hours post injury compared to control axolotls (C). ***; P≤0.001. Error bars represent ± SEM. Scale bar is 75μm.