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. Author manuscript; available in PMC: 2016 Nov 4.
Published in final edited form as: Dev Biol. 2015 Oct 20;408(1):14–25. doi: 10.1016/j.ydbio.2015.10.012

Fig. 9.

Fig. 9

Inhibition of ERK and JNK signaling results in defects in axon regeneration. Inhibition of ERK and JNK signaling cause axonal regeneration defects similar to blocking injury-induced changes in Vmem. Whole mount staining of anti-β-III tubulin 7 days post injury shows that inhibition of (B) ERK signaling or (C) JNK signaling during regeneration blocks axon growth as compared to control axolotls (A). * denotes injury site. Scale Bar 75 μm, N=15 for controls and each inhibitor. Panel (D), western blot analysis of control versus ivermectin treated animals. In vehicle control injured animals dpERK protein levels increase after spinal cord injury, this normal increase of dpERK is inhibited in ivermectin treated animals.